Identification of core genes and transcription factors related to metabolic reprogramming in atherosclerosis: a multi-omics analysis and experimental validation approach - PubMed
3 hours ago
- #metabolic reprogramming
- #multi-omics analysis
- #atherosclerosis
- Identified 57 metabolic reprogramming-related differentially expressed genes (MRDEGs) in atherosclerosis.
- Selected four core genes (LYN, FABP5, MMP9, ANPEP) with high diagnostic value for atherosclerosis.
- Constructed a multi-gene diagnostic model showing strong clinical predictive performance.
- Found significant involvement of core genes in immune-inflammatory pathways via Gene Set Enrichment Analysis (GSEA).
- Identified EGR1 as a key upstream transcription factor regulating the core genes.
- Validated findings in ApoE-/- mice, confirming upregulation of core genes and EGR1 at mRNA and protein levels.