JianPi QingRe HuoXue Formula targets Cadherin-17 to induce apoptosis in chronic atrophic gastritis with intestinal metaplasia - PubMed
7 hours ago
- #Gastric Cancer Prevention
- #Apoptosis Induction
- #Traditional Chinese Medicine
- JianPi QingRe HuoXue Formula (JQHF) targets Cadherin-17 (CDH17) to treat chronic atrophic gastritis (CAG) with intestinal metaplasia (IM).
- JQHF's efficacy was evaluated in clinical patients, animal models, and cell models, showing improvement in gastric mucosal pathology without significant adverse effects.
- Network pharmacology suggested JQHF regulates apoptosis and the Notch pathway.
- Bioinformatic analysis and IHC confirmed elevated CDH17 expression in IM compared to CNAG.
- Molecular docking showed strong binding affinity between JQHF components (e.g., Astragaloside IV) and CDH17.
- JQHF treatment suppressed CDH17, inhibited the Notch pathway, and promoted apoptosis, validated in a CDH17-knockdown mouse model.
- CDH17 knockdown reduced JQHF's therapeutic efficacy, indicating its critical role in JQHF's mechanism.