Cryoablation Activates the cGAS-STING-CXCL10 Axis in Macrophages to Enhance Anti-Tumor Immunity in NSCLC - PubMed
12 hours ago
- #Cryoablation
- #NSCLC
- #Immunotherapy
- Cryoablation shows superior progression-free survival compared to thermal ablation in NSCLC patients with oligoresidual disease post-immunotherapy.
- Single-cell RNA sequencing reveals cryoablation combined with anti-PD-1 expands CXCL10+ macrophages more than thermal ablation.
- CXCR3 blockade and inhibition of T cell egress from lymph nodes negates systemic anti-tumor efficacy.
- Cryoablation releases tumor DNA, which macrophages uptake, activating the cGAS-STING pathway and increasing CXCL10+ macrophages and secretion.
- CXCL10+ macrophages and CXCR3+ T cells are critical mediators of systemic anti-tumor immunity in advanced NSCLC induced by cryoablation.