Statins in Genetic Myopathies: A Retrospective Analysis of Safety and Tolerability - PubMed
4 hours ago
- #genetic myopathies
- #statins
- #rhabdomyolysis
- Statins' safety and tolerability in genetic myopathies were studied in a retrospective analysis.
- The study included 135 patients with various genetic myopathies exposed to statins.
- 26.67% of patients experienced statin-associated muscle symptoms (SAMS), with myalgias being the most common.
- Rhabdomyolysis occurred in 4 patients, particularly in mitochondrial myopathies and McArdle disease.
- Statins unmasked myopathy in 6 out of 36 patients but did not cause immune-mediated necrotizing myopathy.
- Statins are generally safe but not well tolerated in genetic myopathies, requiring close monitoring.
- Caution is advised in mitochondrial and metabolic myopathies due to the risk of rhabdomyolysis.