Towards a physics informed digital twin to predict cerebral blood flow and cerebral vascular regulation - PubMed
6 hours ago
- #Cerebral Blood Flow
- #Digital Twin
- #Neurocritical Care
- The study introduces CereBRLSIM, a digital twin for predicting cerebral blood flow (CBF) and cerebral vascular regulation (CVR).
- CereBRLSIM uses physics-informed models to infer unmeasured CVR mechanisms, such as myogenic, endothelial, and metabolic dynamics.
- It was validated with in vivo experiments and simulated data, showing higher accuracy than machine learning models in neurocritical care patients.
- The approach aims to enable precision diagnostics and improve understanding of cerebral hemodynamics in clinical settings.