Association of the C-reactive protein-triglyceride-glucose index with metabolic dysfunction-associated steatotic liver disease and long-term all-cause and cardiovascular mortality: evidence from two n
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- #mortality
- #cardiometabolic risk
- #MASLD
- The C-reactive protein-triglyceride-glucose index (CTI) is linked to metabolic dysfunction-associated steatotic liver disease (MASLD) and long-term mortality.
- Higher CTI levels are nonlinearly associated with MASLD presence in both U.S. (NHANES) and Chinese (CHARLS) cohorts.
- Elevated CTI in MASLD patients increases risks of all-cause and cardiovascular mortality, with a pronounced threshold effect observed at CTI >5.6.
- Each unit increase in CTI raises cardiovascular death risk by 57% and all-cause death risk by 47% in fully adjusted models.
- Diabetes mediates a substantial proportion of the CTI-mortality association, while body mass index plays a minimal role.
- CTI serves as a robust metabolic-inflammatory marker for cardiometabolic risk stratification in MASLD patients.