The phospholipid profile of T cells shapes ACSL4 dependency and ferroptosis sensitivity of naive, effector, and memory T cells - PubMed
6 hours ago
- #Ferroptosis
- #Phospholipid metabolism
- #T cells
- The study identifies ACSL4 as the main ferroptosis inducer in primary T cells in vitro, with other iron- and lipid metabolism-related genes having minor effects.
- Phospholipid (PL) composition, specifically the presence of polyunsaturated fatty acid-containing PLs (PUFA-PLs), determines ACSL4 dependency and ferroptosis susceptibility; effector CD8+ T cells, rich in PUFA-PLs, undergo ferroptosis without ACSL4.
- Naive and memory T cells share a similar PL profile low in PUFA-PLs, making them resistant to ferroptosis, highlighting PLs as a key factor in differential ferroptosis sensitivity among T cell subsets.