A genetically encoded fluorescent sensor for monitoring spatiotemporal prostaglandin E2 dynamics in vivo - PubMed
3 hours ago
- #fluorescent sensor
- #in vivo imaging
- #prostaglandin E2
- Development of a genetically encoded fluorescent sensor (GRABPGE2-1.0) for monitoring prostaglandin E2 (PGE2) dynamics in vivo.
- The sensor exhibits high specificity for PGE2, nanomolar affinity, rapid kinetics, and high spatial resolution.
- Demonstrated capability to monitor endogenous PGE2 dynamics in the brain during acute inflammation and seizure.
- Reveals spatial heterogeneity in cortex-wide PGE2 dynamics during pathological conditions.
- Provides a robust tool for studying PGE2 in physiological and pathological contexts with high spatiotemporal resolution.