CD8+ T Cell Infiltration Elicits Molecular Subtype-Biased Clinical Outcomes in Gastric Cancer Patients - PubMed
4 hours ago
- #gastric cancer
- #TCGA subtypes
- #CD8+ T cells
- CD8+ T cell infiltration is crucial for antitumor immunity, but its role in gastric cancer (GC) is unclear due to molecular heterogeneity.
- GC is classified into four subtypes by TCGA: EBV-positive, MSI, CIN, and GS, each with distinct immune features.
- High CD8+ T cell infiltration is associated with better overall survival in EBV-positive and CIN subtypes but not in MSI or GS.
- Low CD8+ T cell infiltration predicts better response to adjuvant chemotherapy in MSI patients.
- Immune profiling reveals subtype-specific associations of CD8+ T cells with different immune features, reflecting GC's heterogeneous immunological landscape.