Regulation of YAP activity by nuclear G-actin binding - PubMed
2 hours ago
- #Hippo pathway
- #YAP
- #G-actin
- YAP is a transcriptional co-activator involved in the Hippo pathway, controlling tissue and organ size.
- YAP plays roles in cellular processes like differentiation, proliferation, migration, cancer metastasis, mechanotransduction, and cytoskeletal dynamics.
- The actin cytoskeleton regulates YAP activity through tensile forces, cell density, cell-cell adhesion, and biomechanical cues.
- YAP is identified as a novel G-actin binding protein with three high-affinity actin binding sites in its N-terminus.
- Actin binding to YAP is essential for its transcriptional activity and function, such as in cell density control.
- Mutation of actin-binding residues in YAP leads to loss of its nuclear co-activator function towards TEAD.
- A dynamic TEAD/YAP/actin ternary complex is necessary for transcription.