CSF-Compartmentalized Antibody Glycoprofiles in NMDAR Encephalitis Associate with Etiology and Functional Recovery - PubMed
3 days ago
- #Fc-glycosylation
- #NMDARe
- #autoimmune encephalitis
- Fc-glycosylation profiles in NMDARe patients were analyzed to understand their association with disease triggers and outcomes.
- CSF antibodies showed reduced sialylation and galactosylation compared to serum, indicating a pro-inflammatory response in the CNS.
- Post-herpetic NMDARe cases exhibited more inflammatory Fc-glycoforms than tumor-related or idiopathic cases.
- Reduced sialylation, galactosylation, and fucosylation in CSF and serum were linked to poor 1-year outcomes.
- The study suggests CSF Fc-glycosylation profiles are compartment- and trigger-specific, highlighting distinct pathogenic mechanisms.
- Fc-glycosylation profiling could serve as a potential prognostic biomarker in NMDARe.