The Gut-Tumor Metabolic Axis: A Comprehensive Exploration of Bidirectional Crosstalk in Cancer Immunotherapy - PubMed
3 hours ago
- #Metabolites
- #Cancer immunotherapy
- #Gut microbiome
- The gut-tumor metabolic axis is a bidirectional network where tumor metabolites affect gut microbes and vice versa, influencing cancer progression and immunotherapy outcomes.
- Tumor-derived lactate and acidity suppress immune function and alter gut microbial composition.
- Microbial metabolites like short-chain fatty acids and bile acid derivatives regulate immune responses through specific host pathways.
- Dietary changes, probiotics, and fecal microbiota transplantation can enhance immunotherapy efficacy, but effects depend on context.
- Challenges include safety, donor variability, and the need for biomarker validation in microbiome-based therapies.