Therapeutic Potential of Spermidine in Rheumatoid Arthritis: Mechanisms and Future Directions - PubMed
4 hours ago
- #autoimmune-disease
- #spermidine
- #rheumatoid-arthritis
- Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting joint function and causing systemic complications.
- Current RA treatments include NSAIDs, glucocorticoids, and DMARDs, but a complete cure remains challenging.
- Spermidine (SPD), a natural polyamine, has anti-aging, cardiovascular, neuroregulatory, and anti-inflammatory effects.
- SPD shows therapeutic potential in RA by inhibiting inflammatory cytokines, reducing oxidative stress, and modulating immune cells.
- SPD also helps maintain bone metabolism homeostasis, making it a promising candidate for RA therapy.
- Further large-scale clinical trials are needed to validate SPD's efficacy and safety in RA treatment.