Restorative macrophage-derived RNAseT2 stimulates muscle stem cell fusion via an SLK/N-WASP/actin bundling dependent axis - PubMed
3 hours ago
- #stem cell fusion
- #macrophage signaling
- #muscle regeneration
- Restorative macrophages secrete RNAseT2 to stimulate muscle stem cell (MuSC) fusion during muscle repair.
- RNAseT2 enters MuSCs via the mannose receptor and induces actin bundling, essential for cell-cell fusion, through a SLK/N-WASP dependent pathway.
- In vivo, RNAseT2 overexpression enhances fusion in new myofibers, while RNAseT2-deficient macrophages lead to fusion defects and smaller myofibers.