Stress-associated High Production of Large Extracellular Vesicles in the Parent Generation is Not Inherited by C. elegans F1 Progeny - PubMed
3 hours ago
- #C. elegans
- #heritability
- #exophers
- Parental stress influences stress responses in offspring in C. elegans.
- Proteostress in C. elegans neurons induces the extrusion of aggregates and organelles in large extracellular vesicles called exophers.
- Under mild proteostress, ~20% of ALMR neurons produce exophers.
- The study tested if high exopher production is heritable in C. elegans F1 progeny.
- Offspring of parents that produced exophers showed similar exopher production levels compared to offspring of parents that didn't produce exophers.
- Exopher level changes in response to fasting remained the same in both groups.
- The high exopher production trait is not heritable in C. elegans.