The MetALD-ALD Prediction Index: A Phosphatidylethanol-Driven Biomarker Panel for Identifying Individuals With Steatotic Liver Disease and Excessive Alcohol Use - PubMed
4 hours ago
- #biomarkers
- #alcohol use
- #liver disease
- The MetALD-ALD Prediction Index (MAPI) is a novel biomarker panel for identifying individuals with steatotic liver disease and excessive alcohol use.
- MAPI includes sex, mean corpuscular volume, gamma-glutamyltransferase, high-density lipoprotein cholesterol, and hemoglobin A1c.
- The study involved a derivation cohort of 503 adults and an external validation cohort of 1777 individuals.
- MAPI demonstrated good performance with AUROC scores of 0.76 in the derivation cohort and 0.75 in the validation cohort.
- MAPI outperformed other indirect alcohol biomarkers and can guide confirmatory PEth testing in clinical practice.