Mechanistic Insights into the Cardioprotective Effects of Mesenchymal Stem Cell-Derived Exosomes in Myocardial Ischemic Injury: A Systematic Review - PubMed
7 hours ago
- #Cardioprotection
- #Exosomes
- #Mesenchymal Stem Cells
- MSC-derived exosomes improve cardiac function, reduce infarct size, and preserve myocardial structure in models of myocardial ischemic injury.
- Mechanisms include delivery of miRNAs and lncRNAs that modulate signaling pathways like PI3K/Akt and JAK2/STAT3 to suppress apoptosis, inflammation, and oxidative stress.
- These exosomes promote angiogenesis, enhance mitochondrial integrity, and show potential as low-immunogenicity, cell-free nanotherapeutics for ischemic heart disease.