Reamputation risk and mortality after lower-limb amputation in patients with diabetes: predictors, effects of antidiabetic medications and temporal trends - PubMed
4 hours ago
- #Lower-limb amputation
- #Mortality
- #Diabetes
- Diabetes increases the risk of reamputation and mortality after lower-limb amputation (LLA).
- Metformin usage in type 2 diabetes patients reduces combined reamputation and mortality risk.
- SGLT2 inhibitors are associated with increased reamputation risk but are safe regarding mortality.
- Higher HbA1c levels, older age, atrial fibrillation, and chronic kidney disease elevate reamputation risk in diabetic patients.
- Reamputation risk peaked between 2020-2022, while mortality declined compared to 2006-2010 in diabetic patients.
- The study highlights the need for further research on SGLT2 inhibitors' effects post-LLA.