Targeting cell death in Crohn's disease: from mechanisms to medicines - PubMed
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- #therapeutic targets
- #cell death
- #Crohn's disease
- Crohn's disease (CD) is a chronic inflammatory granulomatous disease affecting the gastrointestinal tract.
- Existing treatments often fail to achieve satisfactory clinical outcomes.
- Programmed cell death plays a key role in CD progression.
- 12 different cell death mechanisms are reviewed: apoptosis, necroptosis, pyroptosis, parthanatos, ferroptosis, autophagy-dependent cell death, cuproptosis, oxeiptosis, entotic cell death, netotic cell death, lysosome-dependent cell death, and alkaliptosis.
- Autophagy, regulated by ATGs, is crucial in CD and linked to genetic factors (ATG16L1, IRGM, NOD2) and the mTOR signaling pathway.
- Apoptosis, pyroptosis, ferroptosis, and copper death are involved in CD pathogenesis.
- Potential therapeutic strategies focus on regulating these cell death pathways.