Analytical Strategies for Fixed-Dose Combination Containing Teneligliptin, Dapagliflozin, and Metformin: A Review - PubMed
6 days ago
- #Fixed-dose combinations
- #Analytical methods
- #Diabetes
- Type 2 diabetes mellitus is a major global health concern.
- Fixed-dose combinations improve glycaemic control and patient adherence.
- No analytical methods exist for simultaneous estimation of teneligliptin, dapagliflozin, and metformin HCl.
- HPLC methods dominate (65%) due to robustness, precision, and stability-indicating capability.
- UV spectrophotometric methods account for 25%, valued for simplicity and cost-effectiveness.
- HPTLC methods (10%) offer rapid and parallel analysis.
- Common HPLC conditions include C18 columns, methanol/acetonitrile-based mobile phases, and detection at 233-246 nm.
- Validation parameters comply with ICH guidelines.
- Review consolidates analytical knowledge and identifies trends for future method development.