VEGF-C-Driven Lymphatic Survival Signaling Promotes Periodontal Repair - PubMed
3 days ago
- #lymphangiogenesis
- #periodontal repair
- #VEGF-C
- Lymphatic vessels are crucial for tissue homeostasis and periodontal repair, but their role in periodontal healing is not well understood.
- The study used a mouse model of ligature-induced periodontitis and advanced imaging techniques to observe lymphatic networks in gingival tissues.
- Findings showed active lymphatic vessel reassembly during healing, with increased branching and density in marginal gingiva, indicating localized lymphangiogenesis.
- Epithelial upregulation of Vegfc was identified during repair, and VEGF-C administration enhanced lymphatic function and alveolar bone repair.
- Primary cultures of gingiva-derived lymphatic endothelial cells (LECs) were established, revealing distinct transcriptomic signatures compared to other LECs.
- VEGF-C signaling in LECs modulated apoptosis-related genes, promoting cell survival.
- The study highlights the regenerative role of lymphatic vessels in periodontium and suggests lymphangiogenic activation as a potential therapeutic strategy.