Age-Related Differences in Severe Adverse Events During Maintenance Therapy with PARP Inhibitors: A Retrospective Cohort Study in Japanese Patients with Ovarian Cancer - PubMed
9 hours ago
- #Ovarian cancer
- #PARP inhibitors
- #Geriatric oncology
- Study evaluates age-related differences in severe adverse events (SAEs) during PARP inhibitor maintenance therapy in Japanese ovarian cancer patients.
- Retrospective cohort study using Japanese Diagnosis Procedure Combination database with 1083 patients.
- Older patients (≥65 years) on olaparib monotherapy had higher incidence of clinically significant neutropenia compared to younger patients (<65 years).
- No significant age-related differences observed in other SAEs, hospitalization, treatment interruption, or discontinuation rates.
- PARP inhibitors generally tolerated in older patients, but careful monitoring and dose management recommended for olaparib monotherapy in older individuals.