Intra-species competition combats vancomycin-resistant enterococci - PubMed
4 hours ago
- #antibiotic resistance
- #VRE
- #microbiota therapy
- Intra-species competition within Enterococcus can suppress vancomycin-resistant Enterococcus (VRE) colonization.
- E. faecalis X98, an antibiotic-susceptible strain, significantly reduces VRE burden in vitro and in mouse models.
- Multi-strain consortia failed due to competitive interference among members.
- Phage selection of E. faecalis OG1RF produced a derivative with glycosyltransferase mutations that secrete a VRE-killing factor.
- The findings provide a framework for developing microbiota-based interventions targeting antibiotic-resistant pathogens with minimal microbiome disruption.