Targeting synovial inflammation in knee osteoarthritis: translational insights for diagnosis and therapy - PubMed
4 hours ago
- #precision-medicine
- #knee-osteoarthritis
- #synovial-inflammation
- Synovial inflammation is central to knee osteoarthritis (OA), linking systemic and local pathogenic pathways with clinical outcomes.
- The review covers synovial structure, function, and molecular mechanisms driving synovitis, including metaflammation, mechanoflammation, mechanotransduction, and immune cell polarization.
- Diagnostic approaches include biochemical biomarkers and imaging modalities, with pain alone being an unreliable disease marker.
- Precision medicine can reshape OA care by integrating clinical phenotypes with molecular endotypes.
- Therapeutic strategies range from current oral and intra-articular drugs to emerging investigational therapies, multitargeting approaches, and novel gene therapies.
- Phenotype- and endotype-informed interventions are advocated for more effective and personalized management of synovitis-driven knee OA.
- The translational value lies in integrating molecular mechanisms with clinical strategies for early diagnosis and refined therapeutic targeting.