Disentangling the gut microbiome and inflammation in inflammatory bowel diseases: longitudinal observations from the IBSEN III study - PubMed
5 hours ago
- #longitudinal study
- #inflammatory bowel disease
- #gut microbiome
- The study used data from the IBSEN III cohort to examine the relationship between gut microbiome changes, inflammation (measured by fecal calprotectin), and clinical disease activity in IBD patients over their first year post-diagnosis.
- Results showed that fecal calprotectin and symptom scores decreased over time in IBD patients, while the gut microbiome exhibited increased alpha diversity and significant taxonomic shifts.
- No covariation was found between changes in microbiome alpha diversity and levels of fecal calprotectin or symptom scores, indicating that microbiome alterations may operate independently of inflammation and symptoms.
- The findings suggest that the gut microbiome could have a disease-driving role in IBD that is distinct from inflammatory processes and associated symptoms.