Glycine Alleviates H2O2-Induced Ferroptosis in Mouse Hippocampal Neuron HT22 Cells via the GlyRɑ1/USP35/FPN1 Signaling Pathway - PubMed
8 hours ago
- #Glycine Signaling
- #Ferroptosis
- #Neuroprotection
- Glycine protects mouse hippocampal neuron HT22 cells from H2O2-induced ferroptosis via the GlyRα1/USP35/FPN1 signaling pathway.
- The study shows glycine improves cell survival, reduces ROS, and upregulates GSH, USP35, GPX4, FPN1, and FTH1 levels.
- Using a GlyRα1 inhibitor confirms glycine's neuroprotective role through this pathway, highlighting its potential in treating oxidative stress-related diseases like ischemic stroke.