T2DM-Induced Gut Dysbiosis Exacerbates Periodontitis Through Intestinal Barrier Disruption and Redox Imbalance - PubMed
4 hours ago
- #T2DM
- #gut dysbiosis
- #periodontitis
- T2DM-induced gut dysbiosis exacerbates periodontitis through intestinal barrier disruption and redox imbalance.
- Multi-omics sequencing (16S rRNA, metagenomics, metabolomics) and fecal microbiota transplantation (FMT) were used to study the mechanisms.
- T2DM-associated gut dysbiosis triggers intestinal barrier disruption, elevating oral oxidative stress and worsening periodontitis.
- Restoring gut microbiota via FMT from healthy donors or protecting the intestinal barrier ameliorates periodontitis.
- Oleic acid (OA) supplementation rescues periodontal damage by activating the SIRT1/FoxO1 pathway and enhancing antioxidant enzymes.
- The study suggests microbiota restoration, intestinal barrier protection, and antioxidant supplementation as adjunctive therapies for T2DM-induced periodontitis.