Wake-promoting neuromodulators in Alzheimer's disease: Implications for sleep and brain clearance - PubMed
7 hours ago
- #Alzheimer's disease
- #sleep regulation
- #glymphatic clearance
- Neuromodulatory subcortical systems (NSS) regulate arousal, cognition, and sleep-wake transitions.
- Dysfunction of NSS is linked to Alzheimer's disease (AD) pathogenesis, occurring in the preclinical phase.
- NSS degeneration affects sleep and impairs glymphatic clearance, which removes amyloid beta and neurotoxic proteins.
- Wake-promoting neuromodulators like norepinephrine, histamine, and orexin influence AD pathology, sleep regulation, and brain fluid dynamics.
- NSS dysfunction may create a cycle of disrupted sleep, impaired clearance, and neurodegeneration, highlighting the need for pharmacological interventions.