Pyruvate is a natural suppressor of interferon signaling by inducing STAT1 protein pyruvylation - PubMed
3 hours ago
- #STAT1
- #pyruvate
- #antiviral immunity
- Pyruvate, a glycolysis end product, suppresses interferon signaling via STAT1 pyruvylation.
- STAT1 pyruvylation at Lys201 disrupts STAT1-STAT2 interaction, inhibiting IFN-I signaling.
- High glucose levels enhance STAT1 pyruvylation, reducing antiviral immunity in humans and mice.
- STAT1-K201R knockin mice show stronger IFN-I antiviral responses.
- Study reveals a non-metabolic role of pyruvate and its impact on immune regulation.
- Findings suggest strategies to enhance IFN-I immunity for viral infection treatment.