Bidirectional associations between functional gastrointestinal disorders and epilepsy and the mediating role of mental health: A population-based study - PubMed
7 hours ago
- #Mental health
- #Functional gastrointestinal disorders
- #Epilepsy
- The study investigates bidirectional associations between functional gastrointestinal disorders (FGIDs) and epilepsy, focusing on mental health's mediating role.
- Using UK Biobank data, Cox models showed FGIDs increase epilepsy risk (HR 1.77) and epilepsy increases FGIDs risk (HR 1.57).
- Mental health mediated 2-6% of these bidirectional associations.
- Mendelian randomization suggested a genetic link between certain intestinal disorders and focal epilepsy with hippocampal sclerosis (OR 1.62).
- No consistent evidence supported epilepsy-to-FGIDs causality.
- The study advocates integrated gut-brain axis strategies, including mental health, for better prevention and management.