RNA Splicing of the FGFR2 Gene Promotes Endothelial Cell Senescence and Atherosclerosis Development - PubMed
5 hours ago
- #endothelial senescence
- #FGFR2 splicing
- #atherosclerosis
- Endothelial cell (EC) senescence is linked to atherosclerosis development.
- FGFR2 alternative splicing (exon IIIb or IIIc) affects receptor function and EC phenotype.
- Elevated FGFR2-IIIc expression correlates with EC senescence and atherosclerotic plaque formation.
- FGFR2-IIIc forms an FGF2-FGFR2-IIIc autocrine loop, promoting senescence via PKCε/STAT3 pathway.
- Splicing factor hnRNP H1 binds to exon IIIb, leading to its skipping under senescence-inducing stimuli.
- EC-specific knockout of FGFR2-IIIc in ApoE-/- mice reduces plaque area and senescence markers.
- FGFR2-IIIc is a potential therapeutic target for age-related atherosclerosis.