Are β-Blockers Necessary for Patients with Heart Failure with Preserved Ejection Fraction? : PurSuit-HFpEF Registry - PubMed
12 hours ago
- #β-blockers
- #heart failure
- #HFpEF
- The effect of β-blockers on heart failure with preserved ejection fraction (HFpEF) remains controversial.
- Patients were divided into two groups: those with atrial fibrillation (AF) and/or ischemic heart disease (IHD) and those without both.
- In patients with AF/IHD, β-blocker use did not affect outcomes like composite endpoint, all-cause death, or HF rehospitalization.
- In patients without AF/IHD, β-blocker use was linked to poorer outcomes, including higher risks of all-cause death and cardiac death.
- Formal interaction testing between β-blocker use and AF/IHD status was not statistically significant across endpoints.
- Routine β-blocker use in HFpEF patients without AF or IHD should be interpreted with caution due to higher mortality-related risks.