Nicotinamide (Vitamin B3) Deficiency in Follicular Fluid of Patients With Ovarian Ageing - PubMed
5 hours ago
- #Ovarian Ageing
- #NAD Metabolism
- #Nicotinamide
- Nicotinamide (Vitamin B3) deficiency is linked to ovarian ageing, with decreased levels in follicular fluid (FF) of affected patients.
- The study found a significant decrease in nicotinamide (NAM) and an increase in its metabolite 1-methylnicotinamide (MNA) in FF, leading to a higher MNA/NAM ratio in patients with ovarian ageing.
- The MNA/NAM ratio negatively correlates with antral follicle count, anti-Mullerian hormone levels, and oocyte retrieval numbers, but positively correlates with age.
- There is a positive correlation between the MNA/NAM ratio in FF and serum, suggesting systemic implications of nicotinamide metabolism in ovarian ageing.
- The findings suggest an imbalance in the nicotinamide degradation pathway, potentially impairing the NAD salvage pathway, and propose nicotinamide supplementation as a countermeasure.
- The study advocates for the MNA/NAM ratio as a potential biomarker for assessing ovarian ageing.