Extracellular vesicle-mediated release of bis(monoacylglycerol)phosphate is regulated by LRRK2 and glucocerebrosidase activity - PubMed
4 hours ago
- #Biomarkers
- #Parkinson's Disease
- #Extracellular Vesicles
- BMP is elevated in Parkinson's patients with LRRK2 and GCase mutations, suggesting a link to extracellular vesicle (EV) release.
- LRRK2 mutant MEFs showed structural endolysosomal alterations, increased EV release, and higher BMP levels, partially normalized by LRRK2 inhibition.
- GCase inhibition further increased BMP levels and EV release in mutant cells, indicating GCase activity modulates BMP regulation.
- Elevated BMP was not due to increased synthesis, despite higher levels of the BMP-synthesizing enzyme CLN5 in mutant cells.
- Pharmacological and imaging studies confirmed BMP release is associated with EV secretion, implicating EVs as potential biomarkers for Parkinson's disease.