Targeted Multidomain Treatment for Mild Traumatic Brain Injury: A Randomized Clinical Trial - PubMed
7 hours ago
- #mTBI
- #neurorehabilitation
- #randomized clinical trial
- The study evaluated a targeted multidomain (T-MD) intervention for mild traumatic brain injury (mTBI) in adults.
- Participants were aged 18 to 49 and within 8 days to 6 months of an mTBI.
- The trial compared T-MD interventions tailored to specific domains with a behavioral management control group.
- Primary outcomes included changes in Neurobehavioral Symptom Inventory (NSI) and Patient Global Impression of Change (PGIC).
- Secondary outcomes focused on domain-specific symptoms, impairments, and adverse events.
- Both groups showed similar improvements in NSI symptom severity and PGIC scores.
- Sensitivity analyses revealed greater improvements in ocular, vestibular, and cognitive symptoms for the T-MD group.
- Adverse events were reported by 6% of participants.
- The findings suggest that both T-MD and control interventions can improve mTBI symptoms similarly.