A beneficial environment promotes immune resilience through epigenetic regulation - PubMed
3 hours ago
- #epigenetic regulation
- #asthma prevention
- #immune resilience
- Beneficial environments, like traditional farms, can enhance immune resilience and reduce allergies and asthma in children.
- Exposure to farm dust (FD) extract reduces allergic lung inflammation and increases monocyte-derived macrophage (MDM) recruitment.
- FD-exposed MDMs show altered gene expression, including reduced Ccl8 and MHC class II, impairing eosinophil recruitment and antigen presentation.
- Epigenetic reprogramming in FD-exposed cells relies on histone deacetylase activity sustained by PPARγ signaling.
- These findings suggest environmental exposures can reprogram immune cells, offering potential strategies for asthma prevention.