T Cell Receptor Signaling and Immune Tolerance: From Autoimmunity to Cancer Immunity - PubMed
4 hours ago
- #TCR signaling
- #cancer immunity
- #autoimmunity
- T cell receptor (TCR) signaling intensity is crucial for thymic selection of conventional T cells (Tconv) and regulatory T cells (Treg), as well as their peripheral activation.
- Reduced TCR signaling leads to a disease spectrum including immune deficiency, latent autoimmunity, and overt autoimmune disease.
- Attenuated TCR signaling, such as through ZAP-70 mutation or reduced expression, increases self-reactivity in Tconv and Treg cells and impairs Treg generation, causing autoimmune and inflammatory diseases.
- Host genetic and environmental factors influence disease phenotype and manifestation.
- Pharmacological reduction of TCR signaling in peripheral T cells can selectively decrease mature Treg cells, enhancing antitumor immune responses.
- TCR-proximal signaling is a key target for modulating autoimmunity and cancer immunity.