Elevated isatin ameliorates heart injury in patients with myocardial infarction after rehabilitation treatment-based metabolomics screening - PubMed
6 days ago
- #cardiac-rehabilitation
- #isatin
- #myocardial-infarction
- Rehabilitation exercise post-myocardial infarction (MI) aids cardiac function recovery.
- Isatin, an endogenous indole derivative, shows anti-inflammatory and antioxidant properties.
- Study investigates isatin's cardioprotective effects in post-rehabilitation AMI patients using multi-omics approaches.
- EECP rehabilitation elevates serum isatin levels in STEMI patients, correlating with improved cardiopulmonary function.
- S100A8 identified as primary target of isatin via HuProt™ microarray and network pharmacology.
- Isatin forms a hydrogen bond with S100A8-GLU41, confirmed by SPR, molecular docking, and dynamics.
- Isatin improves cardiac function in AMI mice and reduces apoptosis in cardiomyocytes.
- Isatin decreases pro-inflammatory cytokine secretion in macrophages.
- EECP upregulates endogenous isatin, which targets S100A8 to reduce oxidative stress and inflammation.