Integrated multi-omics mapping of the causal landscape of gout across the circulating-tissue axis - PubMed
a day ago
- #multi-omics
- #Mendelian randomization
- #gout
- Integrated multi-omics study maps causal relationships in gout across circulating-tissue axis.
- Identified 32 metabolites, one lipid species (TAG 54:3), and two protective plasma proteins (ISLR2, ITIH3) with causal links to gout.
- Triglyceride-rich very-low-density lipoprotein particles and circulating isoleucine are key risk factors.
- Multi-tissue transcriptomic mapping prioritized PRELID1 (kidney), NIPAL1 (liver), LMAN2 (whole blood), and CAD as high-confidence effector genes.
- Functional validation confirmed dysregulation of these genes following inflammatory stimulation.
- Study provides a causal framework linking lipoprotein subfractions, amino acid metabolism, and novel effector genes to gout pathogenesis.