Phage therapy targeting DNA-encapsulated membrane vesicle-producing intestinal symbiotic Klebsiella pneumoniae ameliorates autoimmune disease - PubMed
3 hours ago
- #Klebsiella pneumoniae
- #Autoimmune Hepatitis
- #Phage Therapy
- Isolation of a unique Klebsiella pneumoniae strain (KpA4-1) from an AIH patient that produces DNA-encapsulated membrane vesicles (MVs).
- Administration of these MVs and the KpA4-1 strain in mice worsens autoimmune hepatitis (AIH) by increasing liver enzymes, antinuclear antibodies, and CD8+ T cell infiltration via cGAS-STING pathway activation.
- Targeted bacteriophage therapy against KpA4-1 or using a strain lacking the plasmid (p2) reduces AIH pathology, highlighting potential diagnostic and therapeutic avenues.