The relationship between sarcopenia and all-cause and cardiovascular mortality risk among middle-aged and older adults across stages 0-3 of cardiovascular-kidney-metabolic syndrome: evidence from NHAN
2 hours ago
- #mortality
- #sarcopenia
- #CKM syndrome
- Sarcopenia is significantly associated with increased all-cause and cardiovascular disease (CVD) mortality among middle-aged and older adults.
- The study utilized data from NHANES (2011-2018) and CHARLS (2011-2020) to analyze the relationship between sarcopenia and mortality across stages 0-3 of cardiovascular-kidney-metabolic (CKM) syndrome.
- Multivariable Cox regression analysis showed sarcopenia was linked to higher all-cause mortality (weighted HR = 3.428) and CVD mortality (weighted HR = 1.070).
- Restricted cubic spline (RCS) analysis revealed a nonlinear negative relationship between BMI-adjusted muscle mass (ASMI) and CVD mortality.
- Machine learning models, particularly random forest (AUC=0.766), demonstrated strong predictive performance for mortality risk.
- Validation using the CHARLS cohort confirmed sarcopenia's association with increased all-cause mortality (HR = 2.519).
- Subgroup analysis results were consistent with the main findings, reinforcing sarcopenia's impact on mortality in CKM stages 0-3.