Effects of intravenous furosemide plus small-volume hypertonic saline solutions on inflammatory, remodelling markers and epigenetics signatures of patients with congestive acute decompensated heart fa
10 hours ago
- #hypertonic saline solution
- #acute decompensated heart failure
- #furosemide
- The study compared treatment with intravenous furosemide plus small-volume hypertonic saline solution (HSS) versus furosemide alone in patients with acute decompensated heart failure (ADHF) due to reduced ejection fraction.
- Patients receiving furosemide plus HSS showed higher absolute delta values for IL-6, hsTnT, NT-proBNP, and galectin-3 at post-treatment evaluation.
- After saline load, the furosemide plus HSS group had significantly lower increases in serum concentrations of IL-6, hsTnT, sST2, galectin-3, and NT-proBNP compared to furosemide alone.
- Expression of miR181b decreased more significantly in patients treated with furosemide plus HSS than in those treated with furosemide alone.
- The findings suggest that furosemide plus HSS treatment reduces inflammatory and remodeling markers and modulates miRNA expression in ADHF patients.