GLT8D2-mediated PD-L1 N-glycosylation promotes tumor immune evasion in ovarian cancer peritoneal metastasis - PubMed
3 hours ago
- #glycosylation
- #ovarian cancer metastasis
- #immune evasion
- GLT8D2, a glycosyltransferase, is upregulated in metastatic ovarian cancer and linked to poor prognosis and immune suppression.
- GLT8D2 interacts with PD-L1 to mediate its N-glycosylation at Asn192, enhancing PD-L1 stability and promoting tumor cell migration and invasion.
- PD-L1 N-glycosylation leads to reduced CD8+ T cell infiltration and increased expression of exhaustion markers like LAG3 and PD-1, facilitating immune evasion.
- GLT8D2 knockdown combined with anti-PD-L1 therapy reduces tumor metastasis in vivo, suggesting a potential therapeutic strategy.
- HIF-1α is identified as a direct transcriptional activator of GLT8D2, linking hypoxia to its expression.