Claudins interact with LILRB immune inhibitory receptors to promote myeloid immunosuppression in cancer - PubMed
3 hours ago
- #LILRB2
- #Claudins
- #Myeloid Immunosuppression
- Claudins bind to LILRB2 and LILRB5 immune inhibitory receptors, promoting myeloid immunosuppression in cancer.
- Spatial proximity of LILRB2+ macrophages to CLDN-expressing cancer cells correlates with clinical outcomes and serves as a potential biomarker.
- CLDN18.2-LILRB2 interactions enhance myeloid cell immunosuppression and tumor progression via NF-κB and STAT signaling, reversible by LILRB2 blockade.