Role of transient receptor potential channels on pathogenesis and treatment of psoriasis - PubMed
6 days ago
- #Psoriasis
- #Dermatology
- #TRP Channels
- Psoriasis is a chronic inflammatory skin disease characterized by hyperproliferation of keratinocytes, immune cell activation, and increased sensory neuron innervation.
- Transient Receptor Potential (TRP) channels are identified as potential therapeutic targets for psoriasis due to their involvement in keratinocyte differentiation, immune cell activation, and sensory neuron stimulation.
- Altered expression of TRP subtypes (TRPV1, TRPV3, TRPV4, TRPV6, TRPC6, TRPM8) is observed in psoriasis patients.
- TRPV1 and TRPA1 activation is linked to adverse effects of topical pharmacotherapy and phototherapy, while TRPV1 desensitization (e.g., via capsaicin) can reduce psoriasis severity and pruritus.
- Pharmacological modulation of TRP channels offers a promising strategy for developing safer and more effective psoriasis treatments.