Transcranial temporal interference stimulation targeting the subthalamic region for motor symptoms in Parkinson's disease: a pilot, randomised, double-blind, sham-controlled crossover study - PubMed
4 hours ago
- #Transcranial Stimulation
- #Parkinson's Disease
- #Subthalamic Nucleus
- Transcranial temporal interference stimulation (TIs) targeting the subthalamic region was evaluated for motor symptoms in Parkinson's disease in a pilot, randomised, double-blind, sham-controlled crossover study.
- Thirty participants with early-to-mid-stage Parkinson's disease received a single session of TIs or active sham, with individualised montage based on structural MRI.
- No serious adverse events occurred, and adverse event rates were similar between TIs (70.0%) and sham (77.8%), with a non-significant risk difference.
- The responder rate was significantly higher after TIs compared to sham (70% vs 15%), with a risk difference of 56.3%.
- TIs showed greater reductions in MDS-UPDRS-III total scores at all post-stimulation time points (immediately, 30 min, and 60 min) compared to sham.
- Improvements in bradykinesia and tremor were consistent, while effects on rigidity and axial signs were not.
- TIs was feasible, well-tolerated, and associated with short-term motor symptom improvements, warranting larger trials for efficacy and durability confirmation.