Phenotypes and Clinical Outcome of Heart Failure With Preserved Ejection Fraction Patients in China: Findings From the Chinese Cardiovascular Association Database-Heart Failure Center Registry - PubMe
3 hours ago
- #phenotypes
- #clinical outcomes
- #HFpEF
- HFpEF is a heterogeneous syndrome with challenges in therapeutic development and patient outcomes.
- A novel classification system for HFpEF includes five etiological phenotypes: vascular-related, cardiomyopathy-related, right heart/pulmonary-related, valvular/rhythm-related, and extracardiac disease-related.
- Analysis of 51,466 hospitalized HFpEF patients in China (2017-2021) showed significant differences in baseline characteristics and clinical outcomes across phenotypes.
- Right heart/pulmonary-related, valvular/rhythm-related, and extracardiac disease-related HFpEF had higher adverse outcomes.
- Right heart/pulmonary-related and valvular/rhythm-related phenotypes were linked to increased HF rehospitalization, while extracardiac disease-related HFpEF had higher cardiovascular mortality.
- Prognostic risk factors varied across HFpEF phenotypes.
- Future studies should explore phenotype-specific personalized treatments to improve outcomes, especially in high-risk groups.