Delivery Systems of mRNA Vaccines in the Treatment of Infectious Diseases: From Lipid Nanoparticles to Next-Generation Platforms - PubMed
3 hours ago
- #lipid nanoparticles
- #infectious diseases
- #mRNA vaccines
- mRNA vaccines have revolutionized vaccinology, especially with their success against SARS-CoV-2.
- The delivery system, particularly lipid nanoparticles (LNPs), is crucial for mRNA vaccine efficacy, offering protection, cellular uptake, and immune modulation.
- Current advancements include diverse delivery platforms like polymeric nanoparticles, peptide-based carriers, and extracellular vesicles to address limitations like thermostability and targeted delivery.
- Emerging delivery technologies are being applied to combat various infectious diseases, including influenza, RSV, CMV, HIV, Zika, and Rabies.
- Vaccine design is increasingly tailored to counteract the immune evasion strategies of specific pathogens.