Synergistic immunotherapeutic effects of irreversible electroporation and CAR-NK cell therapy against hepatocellular carcinoma - PubMed
3 days ago
- #immunotherapy
- #hepatocellular carcinoma
- #CAR-NK cells
- CAR-NK cell therapy is a promising immunotherapeutic approach with strong cytotoxicity and safety.
- Hepatocellular carcinoma (HCC) has a suppressive tumor microenvironment (TME) that limits CAR-NK cell efficacy.
- Irreversible electroporation (IRE) reshapes the TME by inducing immunogenic cell death and releasing chemokines like CX3CL1.
- IRE-treated HCC cells show increased susceptibility to NK-mediated cytotoxicity due to elevated reactive oxygen species.
- Combining IRE with GPC3-targeted CAR-NK cells enhances tumor lysis in vitro and tumor regression in HCC models without systemic toxicity.
- The study proposes a clinically actionable treatment paradigm for overcoming resistance in solid tumors like HCC.