ELABELA Protects Against Thoracic Aortic Dissection by Maintaining Vascular Smooth Muscle Cells Homeostasis and Regulating NETosis - PubMed
9 hours ago
- #NETosis
- #Thoracic Aortic Dissection
- #Vascular Smooth Muscle Cells
- ELABELA (ELA) is a novel endogenous ligand for APJ and plays a protective role against Thoracic Aortic Dissection (TAD).
- ELA infusion in mice mitigated TAD development and prevented aortic media degradation, effects reversed by APJ antagonist ML221.
- ELA maintains vascular smooth muscle cell (VSMC) homeostasis and inhibits NLRP3/IL-1β pathway activation.
- ELA modulates neutrophil extracellular trap (NET) formation, linking VSMC signaling to neutrophils.
- Lower plasma ELA levels are associated with an increased risk of TAD in humans.
- ELA shows potential as a therapeutic target and diagnostic marker for TAD management.